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Advanced Microfluidic Platforms for Scalable Organoid Culture
Prof. José L García-Cordero
Institute of Human Biology (IHB) -- Pharma Research and Early Development (pRED). Roche Innovation Center Basel, Basel, Switzerland
Organoids have emerged as pivotal 3D in vitro models for biological research, drug discovery, and personalized medicine. However, challenges persist in generating organoids at scale and, for some organoid types, culturing them in suspension within well plate formats suitable for drug screening. This presentation introduces two technologies designed to address these challenges. The first is a hydrogel droplet-based microfluidic technology that efficiently produces large quantities of organoids. The second is the PulsePlate technology, which enables the growth of organoids in suspension within a well plate format. These technology advancements promise to enhance the efficiency and scalability of organoid-based applications in biomedical research.